ea0065p6 | Adrenal and Cardiovascular | SFEBES2019
Manson Megan
, Adam Safwaan
, Higham Claire
, Keevil Brian
, Trainer Peter
, Monaghan Phillip
Introduction: Late-night salivary cortisol assessment is an important element when investigating suspected Cushings syndrome (CS). The goal of medical therapy is achieving a mean (of 5 samples during a single day) serum cortisol (serumF) of 150300 nmol/l (Cushing Day Curve [CDC]). Metyrapone is an 11β-hydroxylase inhibitor elevating levels of 11-deoxycortisol causing conventional immunoassay (IA) to overestimate SerumF; a problem obviated by LCMS/MS. We ...